English
Amagase Lab. (English)
Research Topic
Exploring methods for the pathological analysis, prevention, and treatment of various gastrointestinal diseases
The gastrointestinal tract is divided into the upper gastrointestinal tract composed of the esophagus, stomach, and duodenum, and the lower gastrointestinal tract composed of the small and large intestines. The pathogenetic factors for diseases in each tract are wide and varied. Although progress has been made in elucidating many of these pathologies, there is a noticeable impact of the aging of society and changes in environment and dietary habits on the gastrointestinal tract. In addition to the expected effects of widely-used treatments for various diseases, damage to the gastrointestinal mucosa is one side-effect that is regarded as problematic. In this laboratory, we are conducting research aimed at proposing safe and appropriate drug therapies by using pharmacological, biochemical, and molecular biological techniques to establish animal models for understanding pathologies and explore the factors involved therein, all in an effort to elucidate the pathogenesis of gastrointestinal injuries (from the esophagus to the large intestine) caused by various clinical drugs (e.g., anti-inflammatory drugs, anti-thrombotic drugs, and anti-cancer drugs). Furthermore, to shed light on the heretofore unknown pathologies of refractory gastrointestinal disorders and functional dyspepsia, we are also exploring the possibility of drug repositioning—that is, identifying new pharmacological effects of approved drugs whose safety and in vivo disposition have been sufficiently demonstrated for humans—to treat gastrointestinal diseases.
Staff
Professor
Kikuko AMAGASE (PhD)
Research Fellow
Students
Graduate student
PhD Course 4th year（Pharmacy）
Shizuka JONAN
PhD Course 1st year（Pharmacy）
Yuuki OTSUKA
Master Course 2nd year（Pharmaceutical Science）
Ryo SUGAHARA
Haruto FUKATSU
Ayana FUJIWARA
Master Course 1st year（Pharmaceutical Science）
Issei IKEDA
Taisei TSUJII
Mai HANEDA
Undergraduate student
6th year (Pharmacy)
Yuu ADACHI
Takumi ITAKA
Anna TANAKA
Ayano HOSHINA
5th year (Pharmacy)
Mika SAITO
Yuuto SUGISAWA
Saori FUKE
Satoshi YAGUCHI
4th year (Pharmacy)
Yui KUWAHARA
Karin SHIMA
Chihiro SHIN
Kirika NISHINAKA
Yujiro FUJINO
Konoka MATSUBARA
4th year (Pharmaceuctial Science)
Chisato OOKI
Syouma KITANISHI
Taito SHINCHI
Kanako NISHIIRI
Mizuki FUKUHARA
3rd year (Pharmacy)
Shota OYAMA
Chihiro KUBOTA
Ayaka SAKAMOTO
Waka SHINOHARA
Sumika HORII
3rd year (Pharmaceuctial Science)
Haruka KAWASHIRI
Yui KITAZAWA
Honoka MASUDA
Tomoha MORIKUBO
Graduates
March, 2023
[Master of Pharmaceutical Science]
Hikaru OTSUKI
Reiichiro SASAKI
[Bachelor]
Naoka UNO
Yuuki OTSUKA
Miyoko TAKAHASHI
Rikako NAKAI
Miyu YAMAMOTO
Issei IKEDA
Taisei TSUJII
Mai HANEDA
March, 2022
[Master of Pharmaceutical Science]
Daisuke KATO
Yuuya MASUDA
[Bachelor]
Kouya KIKUYAMA
Hina KIJIMA
Mayu NOMURA
Hikaru OTA
Ryo SUGAHARA
Haruto FUKATSU
Ayana FUJIWARA
March, 2021
[Bachelor]
Hikaru OTSUKI
Reiichiro SASAKI
March, 2020
[Bachelor]
Daisuke KATO
Yuuya MASUDA
Lab Enrollments
| Nahla Hamouda, MD. PhD. | Egypt | 2019.4〜2021.3 (Research fellow) |
| Nikoo Hasemi | Canada | 2022.9.19〜2022.10.21 |
| Tahani Dakkak | Canada | 2022.10.24〜2022.11.25 |
| Denise Choy | Canada | 2022.11.28~ 2023.1.13 |
| Mikhail Krivykh | Canada | 2023.1.16~ 2023.2.10 |