English
Amagase Lab. (English)
Research Topic
Exploring methods for the pathological analysis, prevention, and treatment of various gastrointestinal diseases
The gastrointestinal tract is divided into the upper gastrointestinal tract composed of the esophagus, stomach, and duodenum, and the lower gastrointestinal tract composed of the small and large intestines. The pathogenetic factors for diseases in each tract are wide and varied. Although progress has been made in elucidating many of these pathologies, there is a noticeable impact of the aging of society and changes in environment and dietary habits on the gastrointestinal tract. In addition to the expected effects of widely-used treatments for various diseases, damage to the gastrointestinal mucosa is one side-effect that is regarded as problematic. In this laboratory, we are conducting research aimed at proposing safe and appropriate drug therapies by using pharmacological, biochemical, and molecular biological techniques to establish animal models for understanding pathologies and explore the factors involved therein, all in an effort to elucidate the pathogenesis of gastrointestinal injuries (from the esophagus to the large intestine) caused by various clinical drugs (e.g., anti-inflammatory drugs, anti-thrombotic drugs, and anti-cancer drugs). Furthermore, to shed light on the heretofore unknown pathologies of refractory gastrointestinal disorders and functional dyspepsia, we are also exploring the possibility of drug repositioning—that is, identifying new pharmacological effects of approved drugs whose safety and in vivo disposition have been sufficiently demonstrated for humans—to treat gastrointestinal diseases.
Staff
Professor
Kikuko AMAGASE (PhD)
Assistant Professor
Sana INOUE (PhD)
Students
Graduate student
PhD Course 4th year（Pharmacy）
Yuuki OTSUKA
Master Course 2nd year（Pharmaceutical Science）
Yui KITAZAWA
Honoka MASUDA
Tomoha MORIKUBO
Master Course 1st year（Pharmaceutical Science）
Nanami ATARASHI
Miyu OTAKE
Yuki YAMANAKA
Undergraduate student
6th year (Pharmacy)
Shota OYAMA
Chihiro KUBOTA
Ayaka SAKAMOTO
Waka SHINOHARA
Sumika HORII
Hanami WATANABE
5th year (Pharmacy)
Itsuki AMENO
Misa Oomura
Misaki KIMURA
Hina TAKASHIBA
Shion HOMMA
Yuka MATSUYAMA
4th year (Pharmacy)
Airi KIRISHIMA
Neo TAKAOKA
Hana TAKAHASHI
Yosuke TSUJI
Kotomi NAKAMURA
Keiko NOGUCHI
4th year (Pharmaceuctial Science)
Koyuki IMAGAWA
Koki Oonishi
Kousei SHINOMIYA
Tomohiro NISHIOKA
Kako YANAGIHARA
Graduates
March, 2023
[Master of Pharmaceutical Science]
Hikaru OTSUKI
Reiichiro SASAKI
[Bachelor]
Naoka UNO
Yuuki OTSUKA
Miyoko TAKAHASHI
Rikako NAKAI
Miyu YAMAMOTO
Issei IKEDA
Taisei TSUJII
Mai HANEDA
March, 2022
[Master of Pharmaceutical Science]
Daisuke KATO
Yuuya MASUDA
[Bachelor]
Kouya KIKUYAMA
Hina KIJIMA
Mayu NOMURA
Hikaru OTA
Ryo SUGAHARA
Haruto FUKATSU
Ayana FUJIWARA
March, 2021
[Bachelor]
Hikaru OTSUKI
Reiichiro SASAKI
March, 2020
[Bachelor]
Daisuke KATO
Yuuya MASUDA
Lab Enrollments
| Nahla Hamouda, MD. PhD. | Egypt | 2019.4〜2021.3 (Research fellow) |
| Nikoo Hasemi | Canada | 2022.9.19〜2022.10.21 |
| Tahani Dakkak | Canada | 2022.10.24〜2022.11.25 |
| Denise Choy | Canada | 2022.11.28~ 2023.1.13 |
| Mikhail Krivykh | Canada | 2023.1.16~ 2023.2.10 |